House undergoes treatment for his hallucinations at Mayfield Psychiatric Hospital, and quickly declares himself cured and ready to leave. The doctor in charge, Darryl Nolan, disagrees and forces House to stay by threatening not to recertify his license until he believes House is cured. A battle of wills begins until House draws closer to the sister-in-law of a catatonic patient, endangers another patient, and admits that he actually does need help.

House returns home to Princeton where he continues to focus on his recovery, but surprises Cuddy with the news that he, 's making a big change in his life. Meanwhile, the team is unable to diagnose a loud-mouthed video game creator who posts each new symptom on the internet and opts for treatments suggested by the online community rather than by the doctors, and Foreman angles for House, 's job, but the pressure to solve the case creates tension in his relationship with Thirteen.

When a controversial African politician falls ill, he is brought to Princeton Plainsboro for treatment. The team struggles with whether to help a merciless dictator being subpoenaed for crimes against humanity in his country. Meanwhile, Wilson tries to make peace with a feuding neighbor, but House’s prying exacerbates the problem.

A wealthy businessman brings his teenage son, who is suffering from inexplicable stomach pains, to Princeton Plainsboro and insists on having Dr. House handle the case. The father of the patient believes the karmic penalty of his financial success is that he is victim to personal tragedy, and that the answer to his son, 's medical mystery lies in a reverse of fate rather than medical treatment. Meanwhile, Foreman and Chase prepare to present information on the Dibala case.

The team takes on the case of a reckless police detective who has a family history of sudden heart failure that killed his father, grandfather and great-grandfather all at age 40. Though House is not keen on diagnosing the patient without any detectable symptoms, the team, urged by Cameron, attempts to identify his condition so the detective can live without fear of dying young. Meanwhile, Chase is haunted by his actions in the Dibala case, and House confronts some ghosts of his own

House, Cuddy, and Wilson go to a medical conference and meet an old friend, while the team deal with a girl whose appendages have swollen but she refuses to tell them the truth about the events leading up to her illness.

While Cuddy deals with her personal relationships, House is finally reinstated and takes on the case of a porn star with eye pain...

It’s Thanksgiving, and the team discover they have little to be thankful for in their personal lives. Meanwhile, House takes on the illness of a brilliant physicist who has rejected his intellect to work as a courier...

When Wilson’s friend and former leukemia patient Tucker suffers paralysis of the arm, Wilson initially insists it’s something other than cancer. House disagrees and offers a wager. However, when Wilson discovers what Tucker’s illness really is, he has to decide whether to make a personal sacrifice to help Tucker live. Meanwhile, Cuddy tries to buy a house for herself and Lucas.

When drug dealer Mickey mysteriously collapses while negotiating a sale, his partner-in-crime, Eddie, accompanies him to Princeton Plainsboro for treatment. But with a major deal pending, Mickey is not forthcoming with the necessary personal information the team needs to treat him. As Mickey, 's condition worsens, the team resorts to old-fashioned detective work to solve the case. Meanwhile, House and Wilson compete for the affection of a new neighbor, and Chase, Thirteen and Taub attempt to play a practical joke on Foreman. '

House and his team take on the case of an ailing businesswoman, Valerie, who suffers from ear pains. As her condition worsens, the doctors realize that Valerie is a clinical psychopath. However, they're not aware if it's a symptom or a psychological condition... and time is running out. '

House and the team rush to treat an ailing college football star in time for the patient to compete in NFL tryouts. But when the patient experiences an onslaught of varied and unusual symptoms, the team has trouble reaching a consensus on how to effectively treat him in time. Meanwhile, Foreman's brother Marcus makes a surprise visit to the hospital.

Cuddy has a day to herself when she has to deal with her personal and professional life, as well as House and his team.

A blogger comes down with bruising and bleeding from the gums, and insists on posting her ailments on the illness despite her boyfriend's wishes. As he tries to solve the case, House discovers a dark secret from Wilson's past and can't resist telling everyone. Wilson seeks revenge and learns a secret about House. Meanwhile, Chase worries that he might be too good-looking.

The team takes on the case of a high school senior who inexplicably blacks out during a class field trip. While in the hospital, the patient repeatedly hallucinates. After exhausting myriad ineffective treatments for her mysterious ailments, House attempts one last controversial approach to diagnosing her: monitoring her cognitive patterns and looking for clues. Meanwhile, Taub airs his dirty laundry at work, and Wilson attempts to furnish his condo.

When a newborn is abducted, Princeton goes into lockdown, and the staff find themselves trapped together. House deals with a dying patient, Taub and Foreman check the personnel records, Cameron asks Chase to sign their divorce papers, and Wilson and Thirteen play Truth or Dare.

When a medieval reenactment knight, Sir William, collapses during a battle, the team takes on the case and Thirteen is intrigued by William's insistence on honor above all else. Meanwhile, House discovers that Wilson is dating his first ex-wife, the "soul-sucking harpy," and vows to break them up to protect Wilson from himself.

House and the team take on the case of a woman Julia, who is in an open marriage and becomes ill during a date with her on-the-side boyfriend. As perplexing as the case is, Julia's happy and healthy, yet polygamous relationship is equally baffling to the team. Meanwhile, House tests Wilson's relationship with Sam.

When a groom collapses at the altar, the team discover that he harbors a secret that will affect their diagnosis. Meanwhile, Wilson pays House's team to take him out, and Taub tries to have an affair despite House's interference.

During a session with Dr. Nolan, House recounts the case of a woman who arrives at the Princeton Plainsboro emergency room with an unexplained illness and no recollection of who she is. While trying to solve the mystery of the woman's illness, House must also help her piece together her identity.

House reluctantly accompanies Cuddy and emergency teams to the site of a crane accident. However, he's more interested in diagnosing the crane operator back at the hospital than dealing with the injured victims... until a trapped victim must decide whether to allow her leg to be amputated to save her life.